On December 13, 2007, jetBlue and Germany-based Lufthansa announced jetBlue's intent to sell 19% of jetBlue to Lufthansa, pending approval from US regulators. Following the acquisition, Lufthansa stated they plan to seek operational cooperation with jetBlue. Lufthansa plans to offer connections to JetBlue flights in Boston, New York (JFK), and Orlando International Airport (no longer a connection).
In July 2016, jetBlue announced commercial flights from the United States to Cuba will commence in late August. On August 31, 2016, JetBlue Flight 387 from Fort Lauderdale–Hollywood International Airport to Abel Santamaría Airport, in Santa Clara, became the first scheduled commercial flight between the United States and Cuba in 55 years. Only charter flights were allowed under previous rules, which required that passengers had to arrive more than 4 hours before the scheduled departure and often endure long lines for documentation checks, late flight arrivals, and pay high baggage fees.
As of April 2019, jetBlue Airways flies to 102 destinations in North, Central, and South America; including destinations in Aruba, The Bahamas, Barbados, Bermuda, Cayman Islands, Colombia, Costa Rica, Cuba, the Dominican Republic, Ecuador, Grenada, Haiti, Jamaica, Mexico, Peru, Puerto Rico, Saint Maarten, Saint Lucia, Trinidad and Tobago, Turks and Caicos Islands, and the United States.